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Adaferin® Gel

Adaferin® Gel is a topical retinoid primarily used to treat acne. This medication has strong comedolytic and exfoliating properties. Adaferin® Gel is formulated for adults and teenagers over 12 years of age.

Other names for this medication:
Adaferin® Cream, Deriva® MS Gel, Apgel, Adiff, Adapen, Adlene, Daple, Differin, Differin Pump, Differin Lotion

Similar Products:
Sotret® Gel, Pernex® Gel, Supatret® Gel, Benzac AC® Gel, A-Ret® Gel, Aczone® Gel, Acnedap® Gel, Brevoxyl® Cream, Aziderm® Cream, Acedapsone, Avlosulfone, Avlosulphone, Croysulfone, Croysulphone, Daps, Dapsoderm-X, Dapson, Dapsone, DDS Pharmaceutical, Diphenasone, Diphone, Dopsan, Dubronax, Dumitone, Eporal

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Adaferin® Gel is manufactured by Galderma. This is a topical medication for mild to moderate acne vulgaris on the face, chest, and back. The active ingredient of Adaferin® Gel is Adapalene, a third-generation retinoid and derivative of vitamin A. It acts as a keratolytic, comedolytic, and exfoliating agent.

Acne vulgaris is a long-term inflammatory skin disorder. Its symptoms are pimples, whiteheads, non-inflamed comedones, and possible scarring. Acne occurs due to the hyperproliferation of P. acnes (Propionibacterium acnes) bacteria, that grow in the clogged pores. Pores get clogged when contain too much skin sebum and excess dead epithelial cells. Our immune system responds to the abnormal amount of P. acnes with acne progression.

MOA (mechanism of action):

Adapalene is considered as a first-line therapy for comedonal and inflammatory acne. It acts as comedolytic and anti-inflammatory agent. Getting deeply into the clogged pores, it modulates cells differentiation and keratinization, therefore decreases the amount of dead skin cells residue and inhibits the formation of pore-clogging content. With the lack of comedogenic content in pores, P. acnes no longer have a positive environment to proliferate in.


Adaferin® Gel is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

Adaferin® Gel is normally applied 1 time daily at bedtime, usually for 3 months. In case your acne has not improved after 2-3 weeks of treatment, discontinue the Adaferin® Gel use and seek medical advice.

How to use Adaferin® Gel:

1. Wash your hands and the affected areas with mild soap or cleanser, pat dry.

2. Apply a thin layer of the gel to the affected areas with your finger tips.

3. Gently rub until the gel is mostly absorbed.

4. Wash your hands after the gel application.


Do not use Adaferin® Gel longer than 6 months.

Do not apply Adaferin® Gel in combination with harsh skin products, medicated soaps and shampoos, products with drying effect on the skin, peeling agents, or products containing alcohol.

Patients should use sunscreens (min. SPF 15) and protective clothing while using Adaferin® Gel.

Do not apply Adaferin® Gel to the irritated, itchy, cracked or burnt skin (sunburns and windburns included).

Do not apply Adaferin® Gel to the open wounds or cuts.

Do not cover the Adaferin® Gel application site with occlusive bandages or other covering.

Do not use Adaferin® Gel in combination with harsh skin products, medicated soaps and shampoos, products with drying effect on the skin, peeling agents, products containing alcohol, spices or lime.

Do not apply skin moisturizers or makeup to the skin being treated with Adaferin® Gel 1 hour before and after the gel application.

Due to the flammable nature of Adaferin® Gel, avoid smoking or being near an open flame while you are applying Adaferin® Gel and immediately after you have used it.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Side effects

The most common side effects associated with the use of Adaferin® Gel are:

  • dry skin
  • itchy skin
  • burning or stinging sensation
  • redness
  • skin rash
  • contact dermatitis
  • redness, itching or swelling of the eyelids

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.


Do not apply Adaferin® Gel if you are allergic to Adapalene.

Do not apply Adaferin® Gel if you have a history of severe allergic reactions associated with the use of retinoids or Vitamin A.

Do not apply Adaferin® Gel if you are allergic to any of the other ingredients comprised in Adaferin® Gel.

Do not use Adaferin® Gel if you are taking any photosensitizers (porfimer, verteporfin), acne medications (salicylic acid) or antifungals (sodium thiosulfate).

Do not use Adaferin® Gel if you have eczema, seborrheic dermatitis or a skin abrasion.

Avoid sunlight (UV) exposure while using Adaferin® Gel, as it may potentiate the side effects of Adapalene.

Do not apply Adaferin® Gel if you have sunburn, windburn or skin irritation with redness, peeling or itching.

Do not use Adaferin® Gel in children under 12 years of age.

Adaferin® Gel is strictly prohibited in women who are pregnant, plan to have a baby or are breastfeeding.

Q: What Adaferin® Gel is used for?

A: Adaferin® Gel is used to treat mild to moderate acne vulgaris.

Q: Can Adaferin® Gel be used in pregnant women?

A: No. Adaferin® Gel is strictly prohibited for women who are pregnant, plan to have a baby or breastfeeding.

Q: Is Adaferin® Gel safe for teenagers?

A: Adaferin® Gel is safe for patients over 12 years old, as long as it used for prescribed conditions and at prescribed doses.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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