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Epzicom

Epzicom is a combination medication containing Abacavir and Lamivudine to treat Human Immunodeficiency Virus type (HIV-1) infection. Epzicom reduces the amount of HIV in the body, keeps it at a low level, increases the count of CD4 cells, which help immune system fight infection. Not for use in individuals under 18 years of age. Epzicom isn't used to treat HIV-2.

Other names for this medication:
Abalam®, A Bec L®, Abamune-L®, Kivexa®

Similar Products:
A Bec®, Virol®, Ziagen, Abamune®, Lamivir®, Lamivir® HBV, Epivir HBV, Tenvir®, Viread, Zidovir®, Efavir®, Stocrin, Nevimune®, Viramune, Atazor®, Reyataz, Daruvir®, Prezista, Ritomune®, Norvir, Isentress®, Zepdon®

Active Ingredient:
Abacavir, Lamivudine

1 bottle

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  $30

USD 204.12 per bottle   -20% USD 255.15 USD 204.12 per bottle   Order now
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3 bottles

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Description

Epzicom comprises two active ingredients called Abacavir (ABC) and Lamivudine (3TC), that belong to a class of synthetic guanosine nucleoside reverse transcriptase inhibitors (NRTIs).

Indications:

Epzicom is indicated with other anti-retroviral agents from different pharmacological classes and not with other nucleoside reverse transcriptase inhibitors (NRTIs).

- treatment of human immunodeficiency virus (HIV-1) infection, as part of a triple-drug regimen.

MOA (mechanism of action):

Abacavir is carbocyclic synthetic nucleoside analogue and Lamivudine is a synthetic nucleoside analogue. Intracellularly, Abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate (CBV-TP), an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its interfering with the growth of viral DNA. Intracellularly Lamivudine is phosphorylated to its active 5′-triphosphate metabolite, lamivudine triphosphate (3TC-TP). Thus, lamivudine triphosphate inhibits RT via DNA chain termination after incorporation of the nucleotide analogue. CBV-TP and 3TC-TP are weak inhibitors of cellular DNA polymerases α, β, and γ.

Dosage

Epzicom can be taken with or without food.

The recommended dose is one tablet daily, in combination with other anti-retroviral agents.

Safety and effectiveness of Epzicom in pediatric patients have not been established.

Some people who take Epzicom may experience:

- Lactic acidosis (a build-up of lactic acid in the body), together with an enlarged liver. Symptoms are deep, rapid breathing, drowsiness, and non-specific symptoms such as nausea, vomiting and stomach pain.

- Hypersensitivity reaction, which may be life-threatening. Discontinue Epzicom as soon as hypersensitivity reaction is developed.

- Liver problems, which may be life-threatening. Tell your healthcare provider immediately if you have any symptoms: dark (tea-colored) urine, yellowing of your skin or whites of your eyes, pale-colored stools, nausea, vomiting, pain or tenderness on your right side below your ribs, loss of appetite, or fatigue.

- Immune reactivation syndrome (severe immune deficiency during combination anti-retroviral therapy (CART) may lead to arousal of opportunistic infections and cause serious clinical conditions), autoimmune disorders. If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness in hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please seek medical advice immediately.

- Accumulation of body fat including central obesity, buffalo hump, peripheral wasting, facial wasting, breast enlargement and cushingoid appearance.

Precautions:

Not everyone responds to treatment with Epzicom in the same way. Your doctor should monitor the effectiveness of your treatment.

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Prior starting Epzicom tablets, review medical history for prior exposure to any abacavir-containing product (including Abacavir, Abacavir/Dolutegravir/Lamivudine, and Abacavir/Lamivudine/Zidovudine) in order to avoid reintroduction in a patient with a history of allergy to Abacavir.

Prior to initiating therapy with Abacavir, screening for the HLA-B*5701 allele is recommended as this decreases the risk of allergic reaction. The carriers of the HLA-B*5701 allele are at a higher risk of a hypersensitivity reaction to Abacavir.

Never restart Epzicom or any other abacavir-containing product following allergic reaction to Abacavir, regardless of HLA-B*5701 status.

Reintroduction of Epzicom or any other abacavir-containing product, even in patients who have no identified history or unrecognized symptoms of allergy to Abacavir therapy, can result in serious or fatal hypersensitivity reactions. Such reactions can occur within hours.

Take special care if you have moderate or severe liver disease, you have ever had liver disease, including hepatitis B or C, you are seriously overweight (especially if you are a woman), you have severe kidney disease.

Consult doctor before taking if you are taking phenytoin (for treating epilepsy), methadone (as a heroin substitute). Abacavir speeds up the removal of methadone from the body. If you are taking methadone, you will be checked for any withdrawal symptoms. Your methadone dose may need to be re-elevated.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Epzicom to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Allergy to Epzicom is a multi-organ clinical syndrome usually characterized by a sign or symptom in 2 or more of the following groups:

  • group 1: fever
  • group 2: rash
  • group 3: gastrointestinal (including nausea, vomiting, diarrhea, or abdominal pain)
  • group 4: constitutional (including generalized malaise, fatigue, or achiness)
  • group 5: respiratory (including dyspnea, cough, or pharyngitis)

Allergy to Epzicom is a multi-organ clinical syndrome usually characterized by a sign or symptom in 2 or more of the following groups:

  • group 1: fever
  • group 2: rash
  • group 3: gastrointestinal (including nausea, vomiting, diarrhea, or abdominal pain)
  • group 4: constitutional (including generalized malaise, fatigue, or achiness)
  • group 5: respiratory (including dyspnea, cough, or pharyngitis)

The most common and uncommon side effects associated with Epzicom are:

  • skin rash
  • nausea
  • vomiting
  • diarrhea
  • stomach pain
  • headache
  • cough
  • nasal irritation
  • runny nose
  • fever
  • muscle pain and discomfort
  • joint pain
  • hair loss
  • tiredness
  • loss of appetite
  • insomnia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Epzicom is contraindicated in patients who are allergic to Abacavir, Lamivudine or any of the other ingredients of Epzicom.

Do not combine Epzicom with abacavir-containing, lamivudine-containing, and emtricitabine-containing products, interferon alfa with or without ribavirin.

Epzicom is contraindicated in patients who carry the HLA-B*5701 allele because they are at high risk for experiencing allergy to Abacavir. Never restart Epzicom or any other abacavir-containing product following allergic reaction to Abacavir, regardless of HLA-B*5701 status.

Epzicom is contraindicated in patients with heart disease, high blood pressure, liver disease, a risk factor for heart disease such as smoking, diabetes, or high cholesterol, or if you have used any other HIV medication in the past.

Epzicom is contraindicated in patients with impaired renal and hepatic function.

Consult your doctor before taking Epzicom if you are pregnant or plan to have a baby.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Q: What is Epzicom used fo?

A: Epzicom is a combination medication containing Abacavir and Lamivudine to treat Human Immunodeficiency Virus type (HIV-1) infection. Epzicom reduces the amount of HIV in the body, keeps it at a low level, increases the count of CD4 cells, which help immune system fight infection. Not for use in individuals under 18 years of age. Epzicom isn't used to treat HIV-2.

Q: Is Epzicom safe?

A: Epzicom is safe if taken as prescribed by your doctor.

Q: Is Epzicom safe during pregnancy?

A: Consult your doctor before taking Epzicom if you are pregnant or plan to have a baby.

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